Zestoretic Drug Interactions

When certain medications are taken with Zestoretic, drug interactions may occur. Some of these drug interactions with Zestoretic may occur when the medication is taken with ibuprofen, codeine, lithium, or muscle relaxants. Drug interactions involving Zestoretic and other medications may result in high blood sugar levels, extremely low blood pressure, decreased effectiveness of the medicines, or other problems.

 

Zestoretic Drug Interactions: An Overview

 Zestoretic® (lisinopril-hydrochlorothiazide) potentially has a number of other medicines with which it may interact. Some of these Zestoretic interactions can involve:
 
o Amobarbital (Amytal®)
o Butabarbital (Butisol Sodium®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
o Thiopental (Pentothal®)
  • Narcotics, such as codeine, morphine, oxycodone, and hydrocodone
     
  • Cholestyramine (Prevalite®, Questran®, Questran® Light, LoCholest®)
     
  • Colestipol (Colestid®)
     
  • Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
     
  • Corticotropin (Acthar®)
     
  • Muscle relaxants, such as tubocurarine.
     
(Zestoretic Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;