More Detail on Zestoretic Interactions
The following sections explain in detail the potentially negative interactions that can occur when
Zestoretic is combined with any of the drugs listed above.
Angiotensin II Receptor Blockers (ARBs)
Combining Zestoretic with an ARB may increase the risk of dangerously low
blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
Diuretics
When taking Zestoretic with a diuretic, your blood pressure may decrease too much. This is more likely to occur when you first start taking Zestoretic. In order to decrease your chances of experiencing this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of Zestoretic, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Zestoretic can interact with
NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have
congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and Zestoretic together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Potassium Supplements or Salt Substitutes With Potassium
If you are taking Zestoretic with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. Ask your healthcare provider about using potassium and Zestoretic together in your situation.
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