Zestoretic Dosing

When treating high blood pressure with Zestoretic, dosing typically starts at either Zestoretic 10 mg/12.5 mg or Zestoretic 20 mg/12.5 mg once a day. Your healthcare provider may adjust your Zestoretic dosage as necessary; however, it may take several weeks to see the full effects of such a change on your blood pressure. It's important to take your Zestoretic dose at the same time each day.

Zestoretic Dosing: An Introduction

The dose of Zestoretic® (lisinopril-hydrochlorothiazide) that your healthcare provider prescribes will vary depending on a number of factors, including:
  • Other medical conditions you may have
  • Other medications you may be taking
  • How you respond to Zestoretic.
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.

Zestoretic Dosing for High Blood Pressure

The recommended dosage of Zestoretic for people with high blood pressure (hypertension) will typically start at Zestoretic 10 mg/12.5 mg or Zestoretic 20 mg/12.5 mg once a day. Based on the initial blood pressure response and/or Zestoretic side effects, the dosage may be increased or decreased. With each change in dosage, it may take several weeks to see the full effects of Zestoretic on lowering blood pressure.

General Zestoretic Dosage Information

Some considerations for people taking Zestoretic include the following:
  • Take your Zestoretic dosage by mouth with a glass of water.
  • You may take your dose of Zestoretic with or without food.  


  • Take Zestoretic at the same time each day to maintain even levels of medicine in the blood.
  • For Zestoretic to work properly, you have to take it as prescribed. The medication will not work if you take it in a way other than how your healthcare provider has prescribed.
  • If you do not take your Zestoretic as scheduled, take your next dose as soon as you remember. If it is almost time for the next scheduled dose, skip the missed one and continue with normal dosing. Do not take a double dose.
  • If you are unsure about anything related to Zestoretic or your Zestoretic dosage, please talk to your doctor, nurse, or pharmacist. Do not stop taking Zestoretic without first discussing it with your healthcare provider.
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Zestoretic Drug Info

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