Twynsta Drug Interactions

More Detail on Twynsta Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when Twynsta is combined with any of the drugs listed above.
 
ACE Inhibitors
Taking an ACE inhibitor with Twynsta may increase your risk for severe low blood pressure (hypotension), high blood potassium (hyperkalemia), and kidney problems. If you take these medications together, your healthcare provider should closely monitor your blood pressure, potassium levels, and kidney function.
 
Aliskiren
Combining Twynsta with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required. Aliskiren and Twynsta should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.  
 
Angiotensin II Receptor Blockers (ARBs)
Twynsta contains an ARB (telmisartan) and should generally not be combined with other ARBs, as this could increase the risk for high blood potassium or other side effects, such as kidney problems and very low blood pressure.
 
Calcium Channel Blockers
Twynsta contains a calcium channel blocker (amlodipine). Therefore, it should generally not be combined with other calcium channel blockers, as this could increase the risk for very low blood pressure, or other side effects, such as dizziness and swelling (edema).
 
Digoxin
Twynsta may increase digoxin levels in the body, increasing your risk for serious side effects. This is most likely to occur when you first start taking this medication or when your Twynsta dosage is increased. If you take these medications together, your healthcare provider should monitor your blood levels of digoxin with a simple blood test. He or she may need to decrease your digoxin dose.
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Twynsta Medication Information

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