Twynsta and Pregnancy

The Risks of Using Twynsta During Pregnancy

Amlodipine, one of the components of Twynsta, has been shown to increase the risk of miscarriages when given in very high doses to pregnant rats. However, there are no studies of amlodipine use in pregnant women.
 
Telmisartan, the other component, caused miscarriages when given in high doses to pregnant rabbits. It also caused miscarriages and decreased infant birth weight when given to pregnant rats at high doses late in pregnancy.
 
More importantly, telmisartan and medications like it have been shown to cause severe problems in pregnant women, especially when used in the second and third trimesters. Problems that occur when using these medications during pregnancy may include:
 
  • Decreased amniotic fluid
  • Kidney problems in the newborn, including kidney failure
  • Low blood pressure in the newborn
  • Face or skull deformity
  • Poor growth of the fetus
  • Premature birth
  • Heart problems
  • Lung problems.
     
There may be rare instances when Twynsta use is necessary during pregnancy. In these cases, the level of amniotic fluid should be monitored regularly and the medication should be stopped if the fluid becomes too low, unless it is necessary to save the mother's life.
 

Final Thoughts

If you are pregnant or thinking about becoming pregnant, let your healthcare provider know. He or she will consider both the benefits and risks of taking Twynsta during pregnancy before making a recommendation in your particular situation.
 
Pregnancy and Pain

Twynsta Medication Information

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