Tribenzor may be a good option for people who are already taking two
blood pressure medications without adequate blood pressure control. It may also be an option for people who are already taking the individual Tribenzor components as three separate pills and would rather take just one pill. Tribenzor is not approved for use as the first-choice medication to treat
high blood pressure.
Who Makes This Medication?
Tribenzor is made by Daiichi Sankyo Europe GmbH for Daiichi Sankyo, Inc.
Tribenzor is a combination of three different prescription blood pressure medications -- olmesartan, amlodipine, and hydrochlorothiazide.
Olmesartan belongs to a class of medications called angiotensin II receptor blockers (or commonly "ARBs"). Angiotensin II is a vasoconstrictor. This means that it narrows the blood vessels, making it harder for the heart to pump blood through them. As a result, blood pressure increases.
Olmesartan blocks angiotensin II receptors, thus preventing angiotensin II from narrowing the blood vessels. Because the blood vessels stay relaxed, blood pressure lowers.
Amlodipine is part of a class of drugs called
calcium channel blockers. It works by slowing down the rate at which
calcium moves into the heart and blood vessel walls. This helps to relax the blood vessels, which improves blood flow and lowers blood pressure. It also makes it easier for the heart to pump blood.
Hydrochlorothiazide (or
HCTZ for short) is a diuretic, commonly referred to as a "water pill." It works by increasing the amount of salt and water removed from the blood by the kidneys. The extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume, and this results in
lower blood pressure.
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