Tribenzor and Breastfeeding

It is not known if it is safe to use Tribenzor (olmesartan medoxomil/amlodipine/hydrochlorothiazide) while breastfeeding. One of the components in this medication has been shown to pass through breast milk. However, it is not known whether the other two components pass through breast milk or what potential risks they may pose to a nursing infant.

Is Tribenzor Safe While Breastfeeding?

Tribenzor™ (olmesartan medoxomil/amlodipine/hydrochlorothiazide) is a prescription medication used to treat high blood pressure (hypertension). It contains three high blood pressure medications -- olmesartan (Benicar®), amlodipine (Norvasc®), and hydrochlorothiazide.
Hydrochlorothiazide, one of the components of Tribenzor, is known to pass through breast milk. It is unknown whether amlodipine and olmesartan, the other two components, also pass through breast milk. Therefore, it is not known if it is safe to breastfeed while using Tribenzor.
If you are breastfeeding a child, talk with your healthcare provider before taking Tribenzor.

More Information on Breastfeeding and Tribenzor

No research has been done to see if Tribenzor passes into breast milk. However, it is possible to look at the information available on using the individual components of the medication while breastfeeding.
Hydrochlorothiazide, one of the components of Tribenzor, is known to pass into breast milk in very small amounts. However, many experts consider small doses (less than 50 mg) of hydrochlorothiazide safe for women to use while breastfeeding. In higher doses, this drug may reduce breast milk production.
It is unknown whether the other two components of Tribenzor, amlodipine and olmesartan, pass into breast milk. Based on their chemical properties, it is expected that they would pass through breast milk. Additionally, olmesartan has been shown to pass into breast milk in rats in small amounts.
In two case reports, amlodipine did not seem to harm nursing infants whose mothers took the medication. However, it is not possible to determine if amlodipine is safe for use while breastfeeding based on this limited information. Additionally, there is no information about the potential effects of olmesartan in a nursing infant.
Although the lack of information about Tribenzor and breastfeeding is certainly frustrating, it is important to keep in mind that studies are rarely done in breastfed infants. Such studies might put the infant, who would otherwise not directly benefit from the medication, at unnecessary risk.
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Tribenzor Medication Information

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