Toprol-XL and Pregnancy

Taking Toprol-XL during pregnancy may present a risk for the unborn child. In animal studies, high doses of the drug caused adverse effects when given to pregnant rats. The FDA has classified Toprol-XL as a pregnancy Category C drug; however, a healthcare provider may prescribe it for a pregnant woman if the benefits to the woman outweigh the risk to the unborn child.

Is It Safe to Take Toprol-XL During Pregnancy?

There may be some risks associated with taking Toprol-XL® (metoprolol succinate) during pregnancy. Toprol-XL is considered a pregnancy Category C medicine by the U.S. Food and Drug Administration (FDA), which means that it has not been studied in pregnant women. In studies involving pregnant rats, however, the drug did seem to have adverse effects on fetuses, especially at high doses. This means there may be an increased risk to the fetus if this drug is used during pregnancy. Your healthcare provider will consider the risk of Toprol-XL, the risk of not treating your condition, and alternative treatment options before making his or her recommendation.
 

Toprol-XL and Pregnancy Category C

The FDA uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
 
A healthcare provider may still prescribe a pregnancy Category C medicine to a pregnant woman in certain situations. For example, untreated high blood pressure during pregnancy carries its own set of significant risks to both the mother and the fetus (see Preeclampsia). In situations like this, a healthcare provider may prescribe a pregnancy Category C medicine for a pregnant woman if the benefit of treating high blood pressure in pregnancy outweighs the risks the medicine may present to the unborn child.
 
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Toprol Medication

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