Toprol-XL and Pregnancy

What Does the Research Say?

Studies of Toprol-XL involving pregnant rats showed an increased risk for postimplantation loss and death shortly after birth in doses up to 55 times the normal human dose. No birth defects were reported; however, animals do not always respond to medicines the same way that humans do.
 
Little human research has been conducted on the effects of Toprol-XL or any other beta blockers on the fetus. With other beta blockers, there have been individual reports of slowed intrauterine growth, small placentas, and birth defects in women who took such medications during pregnancy. There have also been reports of a very low heart rate, low blood sugar, and/or decreased breathing in some women who used beta blockers during childbirth. It is important to note that there have been many women over the years who have taken Toprol-XL (or similar medications) during pregnancy without any problems.
 

Final Thoughts

The FDA has given Toprol-XL a pregnancy Category C classification in response to the results of animal studies and the sporadic reports of problems that occurred when other beta blockers were taken during pregnancy. Toprol-XL could potentially cause harm to your unborn child, but the exact risk is not known.
 
If you become pregnant (or are thinking of becoming pregnant) while taking this medication, let your healthcare provider know. He or she will consider the benefits and risks before making a recommendation in your particular situation. Together, you and your healthcare provider can then decide what is best for you and your child.
 
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