Who Makes This Medication?
Tekamlo is made by Novartis Pharmaceuticals Corporation.
How Does Tekamlo Work?
As mentioned, Tekamlo contains two different medications -- aliskiren and amlodipine -- which work in the following ways:
- Aliskiren is classified as a renin inhibitor and is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It works to convert angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Several different blood pressure medications
work in various steps in this process (such as ACE inhibitors or angiotensin II receptor blockers, known as ARBs). However, aliskiren is different; it acts at the very beginning of the process, preventing renin from converting angiotensinogen to angiotensin I (the first step in the process).