Drug Interactions With Propranolol XL

Numerous medications can potentially cause propranolol XL drug interactions, including nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, and thyroid medicines. These interactions may increase your risk of developing dangerously low blood pressure or breathing problems, a slow heart rate, heart failure, strokes, and many other serious problems.

An Overview of Propranolol XL Drug Interactions

 Propranolol XL (InnoPran XL®) can potentially interact with several other medications. Some of these medicines that may lead to interactions with propranolol XL include:
 
  • ACE inhibitors, including:

 

 

  • Alcohol
  • Alpha blockers, including:

 

 

 

 

  • Certain arrhythmia medications, including:

 

    • Amiodarone (Cordarone®)
    • Disopyramide (Norpace®, Norpace CR®)
    • Lidocaine (Xylocaine®)
    • Propafenone (Rythmol®)
    • Quinidine
    • Sotalol (Betapace®)

 

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), including (but not limited to):

 

 

 

 

  • Reserpine
  • Thyroid medications, including:

 

 

 

 

(The information in this article applies specifically to InnoPran XL. For information about Inderal® LA, a similar medication, see Inderal LA).
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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