Prinzide has not been approved for use in children.
Prinzide is manufactured by Merck & Co.
Prinzide is a combination of two medicines --
Prinivil® (
lisinopril) and
hydrochlorothiazide. Prinivil is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. It helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Prinivil causes blood vessels to relax.
Hydrochlorothiazide is a diuretic (commonly referred to as a "water pill"). It works by increasing the amount of salt and water that the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effect of both Prinivil and hydrochlorothiazide, Prinzide can
lower blood pressure. As a result of its combined effects, Prinzide causes a greater drop in
blood pressure than when either medicine is used alone.