Drug Interactions With Perindopril

More Information on Perindopril Interactions

The following sections explain in detail the potentially negative interactions that can occur if perindopril is combined with any of the drugs listed above.

 

Aliskiren

Combining perindopril with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and perindopril should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.  
 
Angiotensin II Receptor Blockers (ARBs)

Combining perindopril with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.

 
Diuretics
When taking perindopril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when perindopril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of medicine, start you on a lower dose of perindopril, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Perindopril can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and perindopril together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Potassium Supplements
If you are taking a potassium supplement with perindopril, the levels of potassium in your blood may become too high. This can cause serious problems. Talk to your healthcare provider about using potassium and perindopril together in your particular situation.
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Perindopril Medicine

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