More Information on Perindopril Interactions
The following sections explain in detail the potentially negative interactions that can occur if perindopril is combined with any of the drugs listed above.
Diuretics
When taking perindopril with a diuretic, your
blood pressure may decrease too much. This is more likely to occur when perindopril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of medicine, start you on a lower dose of perindopril, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Perindopril can interact with
NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have
congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and perindopril together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Potassium Supplements
If you are taking a potassium supplement with perindopril, the levels of potassium in your blood may become too high. This can cause serious problems. Talk to your healthcare provider about using potassium and perindopril together in your particular situation.
Potassium-Sparing Diuretics
If you are taking both perindopril and a potassium-sparing diuretic, your body may metabolize these medicines differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress more closely if this is the case.
Lithium
If you are taking both perindopril and
lithium, your body may metabolize the drugs differently than intended and increase the lithium levels in the blood. Your healthcare provider may choose to monitor your serum lithium levels more frequently if this is the case.
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