Norvasc Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Norvasc is combined with any of the drugs listed above.
CYP 3A4 Inducers
The body breaks down (metabolizes) Norvasc using liver enzymes known as CYP 3A4 enzymes. Drugs known as CYP 3A4 inducers speed up the activity of these enzymes, causing the body to metabolize Norvasc too quickly. This may make Norvasc less effective.
CYP 3A4 Inhibitors
As stated previously, the body breaks down (metabolizes) Norvasc using liver enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors slow down the activity of these enzymes, causing the body to metabolize Norvasc too slowly. This could increase the level of Norvasc in the blood and increase the risk of side effects.
Different medications inhibit CYP 3A4 enzymes to different extents. Check with your healthcare provider before combining such medications.
Simvastatin
Norvasc increases the level of
simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
It is possible that not all Norvasc drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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