Norvasc Drug Interactions

Norvasc Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Norvasc is combined with any of the drugs listed above.
 
Cyclosporine
Norvasc may increase the level of cyclosporine in the blood, perhaps increasing the risk for side effects. Because it is important for cyclosporine levels to fall within a certain range, your healthcare provider may need to check your blood levels and adjust your cyclosporine dosage if you start or stop taking Norvasc.
 
CYP 3A4 Inducers
The body breaks down (metabolizes) Norvasc using liver enzymes known as CYP 3A4 enzymes. Drugs known as CYP 3A4 inducers speed up the activity of these enzymes, causing the body to metabolize Norvasc too quickly. This may make Norvasc less effective.
 
CYP 3A4 Inhibitors
As stated previously, the body breaks down (metabolizes) Norvasc using liver enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors slow down the activity of these enzymes, causing the body to metabolize Norvasc too slowly. This could increase the level of Norvasc in the blood and increase the risk of side effects.
 
Different medications inhibit CYP 3A4 enzymes to different extents. Check with your healthcare provider before combining such medications.
 
Simvastatin
Norvasc increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
  

Final Thoughts

It is possible that not all Norvasc drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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