Blood Pressure Home > Zestoretic Side Effects

Side effects that are most commonly reported with Zestoretic include dizziness, headache, fatigue, and cough. Rare problems include dry mouth, constipation, and heartburn. Fortunately, if side effects do occur, they tend to be minor; however, if you experience serious problems such as seizures or unexplained swelling of the head or neck, notify your healthcare provider immediately.

An Introduction to Zestoretic Side Effects

As with any medicine, there are possible side effects with Zestoretic® (lisinopril-hydrochlorothiazide). However, not everyone who takes the medicine will experience side effects. If Zestoretic side effects do occur, they are generally mild and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
(This article discusses most, but not all, side effects with Zestoretic. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Zestoretic

Zestoretic has been studied extensively in clinical trials for people with high blood pressure. Before medicines are approved, they must go through several clinical studies where many people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, the side effects are always documented.
As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. In these studies, the most common Zestoretic side effects included:
  • Dizziness -- reported in up to 7.5 percent of people
  • Headache -- reported in up to 5.2 percent of people
  • Cough -- reported in up to 3.9 percent of people
  • Fatigue -- reported in up to 3.7 percent of people
  • Dizziness, lightheadedness, or fainting when standing from a sitting or lying down position (known medically as orthostatic effects) -- reported in up to 3.2 percent of people.
Other side effects of Zestoretic occurring in more than 1 percent of people include, but are not limited to:
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Last reviewed by: Kristi Monson, PharmD;
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