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Tribenzor and Pregnancy Risks

In animal studies, amlodipine, one of the components of Tribenzor, did not cause problems when given to pregnant rabbits. However, it did increase the risk of miscarriages when given in very high doses to pregnant rats. There are no studies of amlodipine use in pregnant women.
Olmesartan, another component in Tribenzor, did not cause problems when given in low doses to pregnant rabbits. Higher doses could not be studied because they caused death in the mother rabbits. Higher doses in pregnant rats caused problems such as decreased infant birth weights and abnormal fetal kidney development.
Medications like olmesartan have been shown to cause severe problems when taken by pregnant women, especially in the second and third trimesters. Problems from using these medications during pregnancy may include:
  • Decreased amniotic fluid
  • Kidney problems, including kidney failure, in the newborn
  • Low blood pressure in the newborn
  • Face or skull deformity
  • Poor growth of the fetus
  • Premature birth
  • Heart problems
  • Lung problems.
Hydrochlorothiazide, the last component in Tribenzor, is known to cross the placenta and pass to the developing fetus. This may cause possible problems in the fetus or newborn infant, including:
  • Jaundice (yellowing of the skin or whites of the eyes)
  • Decrease in the number of platelets in the blood (thrombocytopenia)
  • Low blood sugar (hypoglycemia)
  • Blood electrolyte problems, such as low sodium (hyponatremia) or low potassium (hypokalemia)
  • Death.
There may be very rare instances when it may be necessary for a pregnant woman to use Tribenzor. In these cases, the level of amniotic fluid should be monitored regularly and Tribenzor should be stopped if the fluid becomes too low, unless the medication is considered to be lifesaving for the mother. In addition, the newborn's kidney function and blood pressure should be closely monitored.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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