Tekturna is a drug used to treat high blood pressure. It is the first medication of its kind and is part of a class of drugs called renin inhibitors. This medication works by preventing the renin enzyme from converting other enzymes into a substance that narrows blood vessels. Tekturna comes in tablet form and is taken once a day. Possible side effects include rash, diarrhea, and coughing.
It is made by Novartis Pharmaceuticals Corporation.
How Does It Work?
Tekturna is classified as a renin inhibitor. It is the first medication of its kind. Renin is an enzyme produced in the kidneys that acts throughout the body. It works to convert angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Various blood pressure medications work during different steps in this process (such as ACE inhibitors or angiotensin II receptor blockers, known as ARBs). However, Tekturna is different; it acts at the beginning of the process, preventing renin from converting angiotensinogen to angiotensin I (the first step in the process).
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Tekturna [package insert]. East Hanover NJ: Novartis Pharmaceuticals Corporation;2012 February.
Food and Drug Administration, Center for Drug Evaluation and Research. FDA drug safety communication: new warning and contraindication for blood pressure medicines containing aliskiren (Tekturna) (4/20/2012). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm300889.htm. Accessed April 25, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed February 27, 2008.
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