Tekamlo can decrease the level of furosemide in your blood, possibly making furosemide less effective. If this drug interaction is a concern, your healthcare provider may need to adjust your furosemide dosage if you start or stop taking Tekamlo.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can greatly increase the level of Tekamlo in your blood. These drugs should not be taken together.
Itraconazole can greatly increase the level of Tekamlo in your blood. These drugs should not be taken together.
Ketoconazole can increase the level of Tekamlo in the blood, which could increase your risk of Tekamlo side effects. In order to prevent this drug interaction, your healthcare provider may need to adjust your Tekamlo dosage if you start or stop taking ketoconazole, although this may not be necessary in many cases.
Combining Tekamlo with potassium may increase your risk of high blood potassium (hyperkalemia), a dangerous problem. If you must take these medications together, your healthcare provider should monitor your potassium levels using a simple blood test.
Tekamlo increases the level of simvastatin in the blood, increasing the risk of serious muscle problems or other simvastatin side effects. If you take these medications together, the maximum recommended dosage of simvastatin is 20 mg a day.
Spironolactone Products (Aldactone, Aldactazide)
Combining Tekamlo with spironolactone may increase your risk of high blood potassium (hyperkalemia), a dangerous problem. If you must take these medications together, your healthcare provider should monitor your potassium levels during treatment.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Tekamlo [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2011 October.
Food and Drug Administration, Center for Drug Evaluation and Research. FDA drug safety communication: new warning and contraindication for blood pressure medicines containing aliskiren (Tekturna) (4/20/2012). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm300889.htm. Accessed April 25, 2012.
Tekturna [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2011 February.
Lexi-Interact [computer program]. Lexi-Comp, Inc.; September 14, 2010.
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