Quinaretic is a combination of two medicines -- Accupril® (quinapril hydrochloride) and hydrochlorothiazide. Accupril is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. Accupril helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Accupril causes blood vessels to relax.
Hydrochlorothiazide (HCT for short) is a diuretic (a type of drug commonly referred to as a "water pill"). It works by increasing the amount of salt and water that the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effects of both Accupril and hydrochlorothiazide, Quinaretic can lower blood pressure. As a result of its combined effects, Quinaretic causes a greater drop in blood pressure than when either medicine is used alone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Accuretic [package insert]. New York, NY: Pfizer Inc.;2012 July.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/.
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