Prinzide is a prescription drug used to treat high blood pressure (hypertension) in adults. It is made up of two medicines: a diuretic and an ACE inhibitor. The combined effects of these two medicines result in more significant decreases in blood pressure levels than either does on its own. Side effects of this product may include cough, headache, dizziness, and fatigue.
Prinzide is a combination of two medicines -- Prinivil® (lisinopril) and hydrochlorothiazide. Prinivil is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. It helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Prinivil causes blood vessels to relax.
Hydrochlorothiazide is a diuretic (commonly referred to as a "water pill"). It works by increasing the amount of salt and water that the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effect of both Prinivil and hydrochlorothiazide, Prinzide can lower blood pressure. As a result of its combined effects, Prinzide causes a greater drop in blood pressure than when either medicine is used alone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Prinzide [package insert]. Whitehouse Station, NJ: June 2011.
Zestoretic [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2013 November.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/.
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