Perindopril, a prescription medicine, is commonly used to help control high blood pressure (also known as hypertension). By blocking the angiotensin-converting enzyme that causes blood vessels to constrict, the medication can help blood vessels relax and lower blood pressure. Perindopril comes in tablet form and is available in three different strengths, including 2 mg, 4 mg, and 8 mg.
Brand-name Aceon is manufactured by Solvay Pharmaceuticals. Generic versions are made by various manufacturers.
How Does Perindopril Work?
As mentioned, perindopril is part of a class of drugs called ACE inhibitors. ACE stands for angiotensin-converting enzyme. Perindopril helps to block this enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, the medication causes blood vessels to relax, which can lower blood pressure.
Effects of Perindopril
A blood pressure reading consists of two numbers -- for example, 120/80. The top number is known as the systolic blood pressure, and the bottom number is the diastolic blood pressure. During clinical studies in people taking perindopril, systolic blood pressure decreased, on average, by 9 to 15 mmHg (millimeters of mercury), and diastolic blood pressure decreased by 5 to 6 mmHg, on average. The higher the dose, the greater the drop in blood pressure tended to be.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Aceon [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2013 February.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed December 30, 2009.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click