Blood Pressure Home > Mavik and Pregnancy

Certain side effects or complications may develop with the use of Mavik, and pregnancy problems are a potential risk. Pregnant women are usually not recommended to take Mavik, as the drug can cause temporary or permanent problems, including loss of life, to a fetus. A few of the complications sometimes seen with fetuses or newborns exposed to Mavik during pregnancy include deformities of the head and face, as well as developmental problems with the lungs, cardiovascular system, or nervous system. Despite these warnings, a healthcare provider may still prescribe Mavik to a pregnant woman if its benefits outweigh the possible risk to her unborn child.

Is Mavik Safe During Pregnancy? -- An Overview

Taking Mavik® (trandolapril) during pregnancy is usually not recommended. This is because during pregnancy, Mavik can cause temporary or permanent problems, including death, to the unborn child.

What Is the Risk of Using Mavik During Pregnancy?

Prior to 2006, there was a common belief among healthcare providers regarding the use of Mavik during pregnancy. The feeling was that problems with Mavik and pregnancy were generally seen when the drug was taken during the second or third trimester of pregnancy. However, that changed when a study by researchers at Vanderbilt University was published in the June 2006 edition of the New England Journal of Medicine. This study showed that there may, in fact, also be an increased risk to the fetus if it is exposed to Mavik during the first trimester. Whether the risk to the fetus is as great in the first trimester as in the second or third trimesters is not known.
Some of the complications seen with fetuses or newborns exposed to Mavik during pregnancy include:
  • Extremely low blood pressure (hypotension)
  • Developmental problems with the nervous system
  • Developmental problems with the cardiovascular system (this includes the heart and/or blood vessels)
  • Developmental problems with the lungs
  • Kidney failure
  • Deformities of the head and face
  • Loss of life.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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