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Most people tolerate Lotrel well. However, problems can sometimes occur. The most common side effects of Lotrel include a cough, headache, unexplained swelling, and dizziness. There are also a number of potentially serious side effects that may occur, including an unexplained skin rash, difficulty breathing, or yellowing of the skin. Be sure to report these side effects to your healthcare provider immediately.

An Overview of Lotrel Side Effects

As with any medicine, there are possible side effects associated with Lotrel® (benazepril hydrochloride and amlodipine). However, not everyone who takes Lotrel will experience side effects. In fact, most people tolerate it well. When side effects do occur, in many cases they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects of Lotrel. Your healthcare provider can discuss a more complete list of Lotrel side effects with you.)

Common Side Effects of Lotrel

Extensive clinical trials have looked at the effects of Lotrel on thousands of people worldwide. In these studies, side effects are always documented and compared to side effects that occur in a similar group of people not taking the medicine. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
Based on these studies, the most common Lotrel side effects include:
  • Cough -- occurring in up to 3.3 percent of people (see Lotrel Cough)
  • Headache -- in up to 2.2 percent
  • Unexplained swelling -- in up to 2.1 percent
  • High potassium levels in the blood (hyperkalemia) -- in up to 1.5 percent
  • Dizziness -- in up to 1.3 percent.
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Last reviewed by: Kristi Monson, PharmD;
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