Lotensin HCT is a drug that is used to help lower high blood pressure in adults. The medication works by relaxing the blood vessels and allowing the kidneys to remove more salt and water from the blood, which reduces blood volume. It comes in the form of a tablet that is taken once a day. Side effects may include dizziness, cough, or fatigue.
Lotensin HCT is manufactured by Novartis Pharmaceuticals.
How Does Lotensin HCT Work?
Lotensin HCT is a combination of two medicines: Lotensin® (benazepril) and hydrochlorothiazide. Lotensin is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short. It helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Lotensin causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amounts of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Because of the effects of both Lotensin and hydrochlorothiazide, Lotensin HCT can lower blood pressure. Because of its combined effects, the product causes a greater drop in blood pressure than when either medicine is used alone.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/.
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