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While there may be a link between Inderal and depression, it is not known how common a side effect it is. It is also difficult to say whether the depression is caused by Inderal or by other factors. Common symptoms of depression include feelings of hopelessness, a persistent sad mood, and decreased energy. If you're taking Inderal and depression becomes a problem, your healthcare provider may recommend a different medication.

Inderal and Depression: An Overview

People taking Inderal® (propranolol hydrochloride) may experience various side effects. Depression does appear to be a side effect reported in clinical studies. How commonly it occurred, however, is not known, since this was not reported. Furthermore, given how common depression is in the general population, it is difficult to say whether depression is actually caused by the Inderal, by other specific factors, or by a combination of factors.

Research Findings on Inderal and Depression

What the medical literature has to say about Inderal and depression is probably most ably stated in the title of one research study published by Ried and colleagues: "Beta-blockers and Depression: The More the Murkier?" The fact is that despite a lot of research in this area, healthcare providers cannot say with certainty that beta blockers, including Inderal, cause depression. They also cannot say with certainty that beta blockers do not cause depression.

Inderal and Depression: What Should You Look For?

Depression is extremely common in society today. In fact, in any given one-year period, 9.5 percent of the population (about 18.8 million American adults) suffers from depression. Therefore, knowing the symptoms of depression can be helpful.
Possible depression symptoms may include:
  • Persistent sad, anxious, or "empty" mood
  • Feelings of hopelessness and pessimism
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Decreased energy, fatigue, and being "slowed down"
  • Difficulty concentrating, remembering, and making decisions
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss or overeating and weight gain
  • Thoughts of death or suicide and suicide attempts
  • Restlessness and irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
Keep in mind that there are other conditions that can share similar symptoms with depression.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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