Blood Pressure Home > Fosinopril and Pregnancy

There are several situations where it is not recommended to take fosinopril, and pregnancy is one of them. During any trimester of pregnancy, fosinopril can cause temporary or permanent fetal problems, such as developmental problems with the nervous system, facial deformities, or loss of life. Fosinopril may still be given to a pregnant woman if her healthcare provider believes that its benefits outweigh the possible risks to the unborn child.

Is Fosinopril Safe During Pregnancy?

For people who are pregnant, fosinopril (available as Monopril® and in generic form as Fosinopril Sodium tablets) is usually not recommended. This is because during pregnancy, fosinopril can lead to temporary or permanent problems, including death, in the unborn child.

What Is the Risk of Using Fosinopril During Pregnancy?

Prior to 2006, there was a common belief among healthcare providers regarding the use of fosinopril during pregnancy. The feeling was that problems with fosinopril and pregnancy were generally seen when the drug was taken during the second or third trimester of pregnancy. However, that changed when a study by researchers at Vanderbilt University was published in the June 2006 edition of the New England Journal of Medicine. This study showed that there may, in fact, also be an increased risk to the fetus if it is exposed to fosinopril during the first trimester. Whether the risk to the fetus is as great in the first trimester as in the second or third trimesters is not known.
Some of the complications seen with fetuses or newborns exposed to fosinopril during pregnancy include:
  • Low blood pressure (hypotension)
  • Developmental problems with the nervous system
  • Developmental problems with the cardiovascular system (this includes the heart and/or blood vessels)
  • Developmental problems with the lungs
  • Kidney failure
  • Deformities of the head and face
  • Loss of life.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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