Exforge is commonly prescribed to treat high blood pressure. As a combination medication, it works by relaxing the blood vessels to improve blood flow. Exforge comes in the form of a tablet that is usually taken once a day. Although most people have no problems with the drug, side effects are possible. Common ones include dizziness, water retention, and sore throat.
Exforge contains two medications: amlodipine and valsartan. Amlodipine is a calcium channel blocker. It helps to slow down the rate at which calcium moves into the walls of the blood vessels. This, in turn, helps to relax the blood vessels, which improves blood flow and lowers blood pressure.
Valsartan belongs to a class of drugs called angiotensin II receptor blockers. Angiotensin II is a naturally occurring chemical in the body that causes blood vessels to narrow (constrict). By blocking angiotensin II, valsartan helps to relax the blood vessels, lowering blood pressure.
Effects of Exforge
Exforge has been studied in people with mild-to-moderate high blood pressure. In these studies, the medication lowered blood pressure more than when either amlodipine or valsartan were used alone.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Exforge [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2012 November.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 22, 2012.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed July 18, 2007.
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