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The challenge in determining whether there is a link between doxazosin and depression is that given how uncommon depression has been reported as a side effect of the drug and how common it is within the general population, it is unclear if depression is caused by the medication, other factors, or a combination of both. If you are taking doxazosin and depression symptoms occur, talk to your healthcare provider.

Doxazosin and Depression: An Overview

Several side effects are possible with doxazosin mesylate (Cardura®), and depression may be one of them.
Depression is reported rarely in people taking doxazosin (less than 1 percent). This data comes from clinical trials that extensively studied the drug in thousands of people and documented its side effects. The challenge with doxazosin and depression, however, is that given how uncommon depression is reported with doxazosin and how common it is within the general population, it is difficult to tell whether depression is caused by doxazosin, other factors, or a combination of both.

Doxazosin and Depression: Understanding Clinical Trials

Clinical trials are designed to factor out as many variables as possible in order to understand whether the medicine works and its possible side effects. During a study, some people are given the actual medication, while others are given a placebo (which looks like the actual medication, but does not contain any of the active ingredient).
Side effects occur in people who are taking the medicine and in people who are taking a placebo. By studying both groups, it becomes easy to identify the side effects that are definitely drug-related, those that may be drug-related, and those that have nothing to do with the drug. In clinical studies, depression was reported in 1 percent of people taking doxazosin. However, depression was also reported in 1 percent of people taking the placebo. Therefore, it is not possible to say what role, if any, doxazosin plays in a person developing depression.
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Last reviewed by: Kristi Monson, PharmD;
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