Blood Pressure Home > Avalide Uses
How Does Avalide Work?
The two drugs in Avalide work in different ways to lower blood pressure. Irbesartan belongs to a class of medications called angiotensin II receptor blockers (or commonly "ARBs").
Angiotensin II narrows (constricts) blood vessels, making it more difficult for the heart to pump blood through them. This causes blood pressure to increase. Irbesartan blocks angiotensin II receptors, preventing angiotensin II from narrowing the blood vessels. Because of this action, the blood vessels stay relaxed, and blood pressure lowers.
Hydrochlorothiazide (HCTZ) is a diuretic or "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. The removal of salt and water decreases blood volume, resulting in lower blood pressure.