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More Information on Interactions With Atenolol

The following sections explain in detail the potentially negative interactions that can occur when atenolol is combined with any of the drugs listed above.
 
Alpha Blockers
Combining atenolol with an alpha blocker can increase the risk of dangerously low blood pressure (hypotension). Check with your healthcare provider before combining such medications.
 
Ampicillin (Omnipen, Polycillin, Principen, Totacillin)
Taking ampicillin and atenolol together may decrease the amount of atenolol in the body. If you are taking atenolol and are prescribed ampicillin, let your healthcare provider know. He or she may choose to monitor your situation more closely, consider another antibiotic, and/or adjust your dose of atenolol.
 
Calcium Channel Blockers
Combining atenolol with certain calcium channel blockers may cause a dangerously low blood pressure and (for verapamil or diltiazem), a slow heart rate (called bradycardia). You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine atenolol with a calcium channel blocker.
 
Certain Arrhythmia Medications
Combining atenolol with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine atenolol with an arrhythmia medication.
 
Clonidine
If you take both clonidine and atenolol, stopping clonidine (without stopping atenolol) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking atenolol several days before you gradually reduce the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to atenolol, it is advised to wait several days after stopping clonidine before starting atenolol.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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