Amturnide is a medicine prescribed to treat high blood pressure. This combination product contains three different active ingredients, which work to lower blood pressure by relaxing the blood vessels, improving blood flow, and reducing blood volume. Although most people tolerate this drug well, side effects are possible and may include dizziness, swelling, and headaches.
Amturnide is made by Novartis Pharmaceuticals Corporation.
How Does Amturnide Work?
As mentioned, Amturnide contains three different medications. Amlodipine is a calcium channel blocker. It helps slow down the rate at which calcium moves into the blood vessel walls. This, in turn, helps to relax the vessels, which improves blood flow and lowers blood pressure.
Aliskiren belongs to a class of drugs called renin inhibitors. Renin is an enzyme produced in the kidneys that acts throughout the body. It converts angiotensinogen to angiotensin I. A different enzyme (angiotensin-converting enzyme, or ACE) then converts angiotensin I to angiotensin II, a powerful substance that increases blood pressure by narrowing blood vessels and indirectly stimulating the kidneys to retain salt.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide decreases blood volume. Because of this effect, hydrochlorothiazide can lower blood pressure and also help with water retention.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Amturnide [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2011 April.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. November 10, 2011.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed November 10, 2011.
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