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Depression is a rare Accupril side effect, occurring in less than 1 percent of people who take the drug. Because of how uncommonly depression is reported in people taking Accupril and how common it is in society today, it is difficult to say how closely depression and Accupril treatment are linked. A few symptoms of depression include feelings of hopelessness and pessimism; loss of interest or pleasure in hobbies and activities that were once enjoyed; and thoughts of death or suicide, as well as suicide attempts. If you have a history of depression and are prescribed Accupril, talk with your healthcare provider.

Is Depression an Accupril Side Effect?

There are several possible side effects for people taking Accupril® (quinapril hydrochloride). Depression appears to be a rare complaint in people taking this medication. In clinical studies, depression was reported in less than 1 percent of people who took Accupril. Given how common depression is in the general population and how rare a complaint it is in people who take Accupril, it is difficult to say whether depression is caused by the medicine, specific factors, or a combination of factors.

Depression and Accupril: What to Look For

While depression may not be a commonly reported side effect of Accupril, it is extremely common in society today. In fact, in any given one-year period, 9.5 percent of the population (about 18.8 million American adults) suffers from depression. Therefore, knowing the symptoms of depression can be helpful.
Possible depression symptoms may include:
  • Persistent sad, anxious, or "empty" mood
  • Feelings of hopelessness and pessimism
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Decreased energy, fatigue, and being "slowed down"
  • Difficulty concentrating, remembering, and making decisions
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss or overeating and weight gain
  • Thoughts of death or suicide; suicide attempts
  • Restlessness and irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
Keep in mind that there are other conditions that can share similar symptoms with depression.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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