Lotrel Drug Interactions

Injectable Gold
Reactions have been reported in people taking Lotrel who received gold injections. These reactions included symptoms such as facial flushing, nausea, vomiting, and low blood pressure.
 
Lithium
Lotrel may increase the risk of lithium toxicity and may increase the lithium levels in the blood. Your healthcare provider may choose to monitor your blood lithium levels more frequently and may need to adjust your lithium dosage.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking both NSAIDs and Lotrel may add to the damage that your kidneys are already experiencing. Also, NSAIDs may decrease the effects of Lotrel on lowering your blood pressure. For your particular situation, talk to your healthcare provider about using NSAIDs and Lotrel together.
 
Potassium Supplements or Salt Substitutes With Potassium
If you are taking Lotrel along with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium supplements or salt substitutes and Lotrel together.
 
Potassium-Sparing Diuretics
If you are taking Lotrel and a potassium-sparing diuretic, your blood pressure may decrease too much and/or the levels of potassium in your blood may become too high. Your healthcare provider may choose to monitor your progress closely.
 
Simvastatin
Lotrel increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
  
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