Lotrel Drug Interactions

Lotrel Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lotrel is combined with any of the drugs listed above.
 
Aliskiren
Combining Lotrel with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and Lotrel should never be combined in people with diabetes, because they have may a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.  
 
Angiotensin II Receptor Blockers (ARBs)
Combining Lotrel with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Antacids
Taking antacids with Lotrel may decrease the absorption of Lotrel into the body. If you are taking antacids, they should be taken at least two hours before or after taking Lotrel.
 
Diuretics (Demadex, Lasix)
When taking Lotrel with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Lotrel is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dose of the diuretic, start you on a lower dose of Lotrel, and/or monitor you more closely.
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Lotrel Medication

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