Lotrel Drug Interactions (Cont.)

More Detail About Lotrel Interactions

 
Diuretics (Demadex, Lasix)
When taking Lotrel with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Lotrel is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dose of the diuretic, start you on a lower dose of Lotrel, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking both NSAIDs and Lotrel may add to the damage that your kidneys are already experiencing. Also, NSAIDs may decrease the effects of Lotrel on lowering your blood pressure. For your particular situation, talk to your healthcare provider about using NSAIDs and Lotrel together.
 
Potassium Supplements or Salt Substitutes With Potassium (Aldactone, Dyrenium, Midamor)
If you are taking Lotrel along with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium supplements or salt substitutes and Lotrel together.
 
Potassium-Sparing Diuretics
If you are taking both Lotrel and a potassium-sparing diuretic, the levels of potassium in your blood may become too high. To decrease the chances of this interaction, your healthcare provider may choose to monitor your progress more closely.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
If you are taking both Lotrel and lithium, your body may metabolize the drugs differently than intended and increase the levels of lithium in the blood. Your healthcare provider may choose to monitor your serum lithium levels more frequently.
 
(Lotrel Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;