Drug interactions with Lotensin can increase the levels of the drugs in your body and change the way your body metabolizes them. A few of the drugs that can potentially interact with Lotensin include nonsteroidal medicines like naproxen sodium, meloxicam, and indomethacin; diuretics like torsemide and hydrochlorothiazide; and potassium-sparing diuretics like spironolactone and amiloride. Be sure to talk with your doctor about any Lotensin drug interactions that may apply to you.