Lopressor Interactions

Cimetidine (Tagamet)
If you are taking Lopressor and cimetidine together, your body may metabolize Lopressor differently than intended. This can cause an increased level of Lopressor in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your Lopressor dose if needed.
 
Clonidine
If you take both clonidine and Lopressor, stopping clonidine (without stopping Lopressor) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. You should stop taking Lopressor several days before you gradually reduce the dose of clonidine. However, do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to Lopressor, it is advised to wait several days after stopping clonidine before starting Lopressor.
 
Digoxin
Combining Lopressor with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, it is not recommended to combine Lopressor with digoxin.
 
Diphenhydramine (Banophen, Benadryl)
If you are taking Lopressor and diphenhydramine together, your body may metabolize Lopressor differently than intended. This can increase the level of Lopressor in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your Lopressor dose if needed.
 
Hydroxychloroquine (Plaquenil)
If you are taking both Lopressor and hydroxychloroquine, your body may metabolize Lopressor differently than intended. This can cause an increased level of Lopressor in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your dose of Lopressor.
(Lopressor Interactions Continued: Page 4)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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