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Lisinopril Drug Interactions
Interactions with lisinopril can change how your body metabolizes the drugs, decrease blood pressure too much, or contribute to kidney damage. Some of the medicines that can potentially react with lisinopril include potassium-sparing diuretics, lithium, and nonsteroidal anti-inflammatory drugs. If drug interactions are a concern, your healthcare provider may adjust your dosages or monitor you more closely.
Lisinopril (Zestril®) can potentially react with a number of other medicines. Some of these lisinopril drug interactions can include:
- Aliskiren (Tekturna®) or aliskiren combination medications (Tekamlo®, Tekturna HCT®, Amturnide®)
- Angiotensin II receptor blockers (ARBs), such as:
- Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
- Candesartan (Atacand®) or candesartan-hydrochlorothiazide (Atacand HCT®)
- Eprosartan (Teveten®) or eprosartan-hydrochlorothiazide (Teveten® HCT)
- Irbesartan (Avapro®) or irbesartan-hydrochlorothiazide (Avalide®)
- Losartan (Cozaar®) or losartan-hydrochlorothiazide (Hyzaar®)
- Olmesartan (Benicar®), olmesartan-hydrochlorothiazide (Benicar HCT®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis®) or telmisartan-hydrochlorothiazide (Micardis® HCT)
- Valsartan (Diovan®) or valsartan-hydrochlorothiazide (Diovan HCT®)
- Diuretics, such as torsemide (Demadex®), furosemide (Lasix®), hydrochlorothiazide, and others
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cambia™, Cataflam®, Flector®, Pennsaid®, Solaraze® Gel, Voltaren®, Voltaren® Gel, Voltaren®-XR, Voltaren Ophthalmic®, Zipsor™)
- Etodolac (Lodine®, Lodine® XL)
- Ibuprofen (Motrin®, Advil®, Nuprin®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen (Orudis®, Actron®, Oruvail®)
- Ketorolac (Sprix™, Toradol®)
- Meloxicam (Mobic®)
- Nabumetone (Relafen®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Oxaprozin (Daypro®)
- Piroxicam (Feldene®)
- Others (see List of NSAIDs for a more complete list of these medications)
- Potassium supplements
- Potassium-sparing diuretics, such as spironolactone (Aldactone®), triamterene (Dyrenium®), and amiloride (Midamor®), among others
- Lithium (Eskalith®, Lithane®, Lithonate®, Lithotabs®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD