Lisinopril Drug Interactions (Cont.)

Lisinopril Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when lisinopril is taken with any of the medications listed above.
 
Diuretics
When taking lisinopril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when lisinopril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of lisinopril, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs
If you have kidney disease or kidney failure, taking NSAIDs and lisinopril together may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of lisinopril. Talk to your healthcare provider about using NSAIDs and lisinopril together in your particular situation.
 
Potassium Supplements
If a potassium supplement and lisinopril are combined, the levels of potassium in your blood may become too high. This can cause serious problems. Ask your healthcare provider about using potassium and lisinopril together in your particular situation.
 
Potassium-Sparing Diuretics
When taking both lisinopril and a potassium-sparing diuretic, your body may metabolize these drugs differently than intended and/or increase the levels of potassium in your blood. To prevent this interaction, your healthcare provider may choose to monitor your progress more closely.
 
Lithium
When lisinopril and lithium are taken together, your body may metabolize the drugs differently than intended, which can increase the levels of lithium in the blood. Your healthcare provider may choose to monitor your serum lithium levels more frequently to prevent this interaction from occurring.
 
(Lisinopril Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;