Lisinopril Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
lisinopril is taken with any of the medications listed above.
Angiotensin II Receptor Blockers (ARBs)
Combining lisinopril with an ARB may increase the risk of dangerously low
blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
Diuretics
When taking lisinopril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when lisinopril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of lisinopril, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Lisinopril can interact with
NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have
congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and lisinopril together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Potassium Supplements
If a potassium supplement and lisinopril are combined, the levels of potassium in your blood may become too high. This can cause serious problems. Ask your healthcare provider about using potassium and lisinopril together in your particular situation.
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