Lisinopril and Pregnancy

A recent study on lisinopril and pregnancy showed that the drug may pose a risk to the fetus at any stage of pregnancy -- not just the second and third trimesters. Complications seen in fetuses or newborns exposed to lisinopril during pregnancy include kidney failure, developmental problems, and loss of life. If you're taking lisinopril and pregnancy occurs, your healthcare provider will weigh the benefits and risks before making a recommendation.

Lisinopril and Pregnancy: An Overview

Lisinopril (available as Zestril®, Prinivil®, and generic lisinopril) is usually not recommended for women who are pregnant. During pregnancy, lisinopril can cause temporary or permanent problems for the unborn child, including death.
 

Lisinopril and Pregnancy: What's the Risk?

Prior to 2006, many healthcare providers believed that problems with lisinopril and pregnancy were generally seen when the drug was taken during the second or third trimester. However, that changed when a study by researchers at Vanderbilt University was published in the June 2006 edition of the New England Journal of Medicine. This study showed that there may, in fact, also be an increased risk to the fetus if it is exposed to lisinopril during the first trimester. Whether the risk to the fetus is as great in the first trimester as in the second or third trimester is not known.
 
Some of the complications seen with fetuses or newborns exposed to lisinopril during pregnancy include:
 
  • Extreme low blood pressure (hypotension)
  • Developmental problems with the nervous system
  • Developmental problems with the cardiovascular system (this includes the heart and/or blood vessels)
  • Developmental problems with the lungs
  • Kidney failure
  • Deformities of the head and face
  • Loss of life.
 
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Lisinopril (Zestril, Prinivil)

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