Labetalol and Weight Gain

Gradual weight gain does not appear to be a side effect of labetalol; however, if this problem occurs, there are a number of things you can try, such as eating a heart-healthy diet and exercising regularly. Report any rapid weight gain with labetalol to your healthcare provider immediately -- it may be a sign of congestive heart failure.

Does Labetalol Cause Weight Gain?

There are a number of possible side effects with labetalol hydrochloride (sold under the brand name Trandate® and available as a generic). Gradual weight gain, however, does not appear to be one of them. Rapid weight gain, on the other hand, is a reported side effect with many beta blockers.

Understanding Clinical Trials

Before medicines are approved, they must go through several clinical studies, where thousands of people are given a particular medicine and compared to a group of people who were not given the medicine. In these studies, side effects are always documented. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Side effects are then usually separated into those that occur in more than 1 percent of people (considered common) and those that occur in less than 1 percent of people (considered rare).
For people taking labetalol, gradual weight gain was not reported as either a common or rare side effect.

Rapid Weight Gain With Labetalol

One important point to keep in mind related to labetalol and weight gain is that all beta blockers may worsen congestive heart failure or, in some cases, even cause the condition. One of the main symptoms of heart failure is unexplained weight gain. In fact, people with symptoms of congestive heart failure can often have rapid weight gain (three to five pounds) over several days. This weight gain is often combined with other symptoms, such as a cough and swelling in the ankles, feet, or legs.
Make sure to contact your healthcare provider if you notice unexplained weight gain or swelling while taking labetalol.
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Labetalol HCl

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