Drug Interactions With Labetalol

More Detail on Interactions With Labetalol

The following sections explain in detail the potentially negative interactions that can occur when labetalol is combined with any of the drugs listed above.
Cimetidine (Tagamet)
If you are taking labetalol and cimetidine together, your body may metabolize labetalol differently than intended. This can result in an increased level of labetalol in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and adjust your labetalol dose as needed.
Calcium Channel Blockers
If you are taking labetalol with a calcium channel blocker, your blood pressure may decrease too much or your heart rate may slow dramatically. This can cause symptoms such as a spinning sensation (vertigo), lightheadedness, dizziness, or fainting. You are also at increased risk for developing congestive heart failure or a very slow heart rate. If you are taking labetalol and a calcium channel blocker together, your healthcare provider may choose to monitor your situation more closely, adjust your dose of these medicines, or both.
Certain Diabetes Medicines
Taking certain types of diabetes medicines with labetalol may increase the effects of the diabetes medicine, causing blood sugar levels to drop too low (hypoglycemia) or may mask some of the symptoms of hypoglycemia. If you are taking diabetes medication with labetalol, your healthcare provider may adjust your dosages, monitor you more closely, or both.
Tricyclic Antidepressants
People taking labetalol with a tricyclic antidepressant may be at increased risk for tremors. In clinical studies, these tremors were seen in 2.3 percent of people who took labetalol with a tricyclic antidepressant. Your healthcare provider may choose to monitor you more closely and change your medicines if needed.
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