Inderide and Pregnancy

Research has shown that Inderide (propranolol/HCTZ) may not be safe for women during pregnancy. Some of the problems this drug may cause in a developing fetus or newborn include birth defects and slowed growth. However, because high blood pressure can be harmful to both the mother and the fetus, a healthcare provider may still prescribe this drug if the benefits outweigh the risks.

Can Pregnant Women Take Inderide?

Inderide® (propranolol/HCTZ) is a prescription combination medication used to lower blood pressure in people with hypertension (high blood pressure). It contains propranolol (Inderal®) and hydrochlorothiazide (Microzide®, Oretic®), often called HCTZ for short. Based on the results of animal studies, Inderide may not be safe for use during pregnancy.

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been adequately studied in pregnant humans but did appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.

What Are the Risks of Taking Inderide When Pregnant?

Inderide, which is a combination medication, has not been studied in pregnant animals or pregnant women. However, there is information available about the individual medications in Inderide from animal studies, as well as reports from human use during pregnancy.
Propranolol, one of the active ingredients in Inderide, did not seem to cause problems in the fetus or newborns when given in high doses to pregnant and lactating rabbits. However, it caused miscarriages and newborn death when given in high doses to pregnant rats. It is important to note that animals do not always respond to medicines in the same way that humans do.
There have been reports of birth defects, slowed growth, and small placentas in babies whose mothers took propranolol during pregnancy. In addition, there have been reports of a very slow heart rate, low blood sugar levels, and breathing problems in some newborns whose mothers took propranolol just before or during childbirth.
Hydrochlorothiazide, the other active ingredient in Inderide, did not cause any fetal problems when given in high doses to pregnant rats or mice. However, there have been reports of problems in the fetus or newborns of women who took HCTZ during pregnancy. Some of these problems included jaundice (yellowing of the skin or whites of the eyes) and a decrease in the number of platelets in the blood (thrombocytopenia).
A pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes the benefits to the woman outweigh any possible risks to her unborn child. Untreated high blood pressure during pregnancy can be harmful to both the pregnant woman and the developing fetus (see Preeclampsia). In some cases, treatment with a pregnancy Category C medication may be the best option with the least amount of risk.
Pregnancy and Pain

Inderide Medication Information

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