Hyzaar Drug Interactions

More Detail About Hyzaar Interactions

The following sections explain in detail the potentially negative interactions that can occur when Hyzaar is combined with any of the drugs listed above.


ACE Inhibitors
Although not an ACE inhibitor, Hyzaar works similarly to ACE inhibitors. Thus, combining these drugs may increase the risk of high potassium levels (hyperkalemia), kidney failure, and dangerously low blood pressure. Careful monitoring is necessary for such combinations.
When taking Hyzaar with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Hyzaar is first started. In order to decrease the chances of this Hyzaar interaction, your healthcare provider may start you on a lower dose of Hyzaar and/or monitor you more closely.
Potassium Supplements or Salt Substitutes With Potassium
If you are taking Hyzaar along with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and Hyzaar together.
Potassium-Sparing Diuretics
If you are taking both Hyzaar and a potassium-sparing diuretic, your body may metabolize them differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress closely.
Rifampin (Rifadin, Rimactane, Rofact)
If you are taking Hyzaar and rifampin together, your body may metabolize Hyzaar differently than intended. This can cause a decreased level of Hyzaar in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your Hyzaar dose as needed.
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Hyzaar Drug Info

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