Hydrochlorothiazide Risks

Even though most people respond well to hydrochlorothiazide (HCTZ), risks associated with the medication should be reviewed before treatment begins.
People generally tolerate this drug well, but as with any medication, side effects are possible. Some of the side effects that were reported with hydrochlorothiazide during clinical studies included:
  • Weakness, dizziness, or a spinning sensation (vertigo)
  • Low blood pressure (hypotension)
  • Diarrhea, nausea, vomiting, constipation, and stomach cramps
  • Increased blood sugar (hyperglycemia).
Hydrochlorothiazide is also more likely than other drugs to cause allergic reactions. People with a history of asthma or allergies may be more likely to have an allergic reaction to this medicine. Make sure to discuss these risks with your healthcare provider before taking hydrochlorothiazide. Also, seek emergency medical attention immediately if you notice things such as hives, an unexplained rash, difficulty breathing, or swelling of the face or throat.
(Click Side Effects of Hydrochlorothiazide and Hydrochlorothiazide Warnings and Precautions to learn about other potential risks of hydrochlorothiazide, to find out what other side effects may occur, and for information on who should not use this particular drug.)
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