Hydrochlorothiazide Drug Interactions

Cholestyramine (Prevalite, Questran, Questran Light, LoCholest)
Cholestyramine can bind to hydrochlorothiazide in the digestive tract and decrease its absorption into the body. To avoid this drug interaction, hydrochlorothiazide should be taken at least one hour before or four to six hours after cholestyramine has been given.
 
Colestipol (Colestid)
Colestipol can bind to hydrochlorothiazide in the digestive tract and decrease its absorption into the body. To avoid this drug interaction, hydrochlorothiazide should be taken at least one hour before or four to six hours after colestipol has been given.
 
Corticosteroids
Taking corticosteroids with hydrochlorothiazide may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking a corticosteroid with hydrochlorothiazide, your healthcare provider may monitor you more closely and/or adjust your dose of medicine as needed.
 
Norepinephrine
Norepinephrine is a medicine that is used to treat very low blood pressure. Hydrochlorothiazide may affect norepinephrine's ability to raise blood pressure.
 
Corticotropin
Taking corticotropin with hydrochlorothiazide may cause an electrolyte imbalance, especially with the levels of potassium in the blood. If you are taking corticotropin with hydrochlorothiazide, your healthcare provider may monitor you more closely and/or adjust your dosage as needed.
 
Muscle Relaxants
If you are taking hydrochlorothiazide with a muscle relaxant, your body may metabolize the drugs differently than intended and increase the muscle relaxant levels in the blood. In order to decrease the chances of developing this drug interaction, your healthcare provider may monitor you more closely and/or change the muscle relaxant dose.
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Hydrochlorothiazide (HCTZ) Drug Information

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