Hydrochlorothiazide should be taken at the same time each day to maintain an even level of hydrochlorothiazide in your blood. However, some people do not need to take hydrochlorothiazide every day, especially people taking it for fluid retention.
Because hydrochlorothiazide increases urination, it is best to take it in the morning (to avoid needing to get up to use the bathroom throughout the night). If you take hydrochlorothiazide multiple times per day, it is best to take the last dose of the day before 6 PM (unless you are instructed otherwise).
For hydrochlorothiazide to work properly, you have to take it as prescribed; it will not work if you stop taking it.
If you are unsure about anything related to hydrochlorothiazide or your hydrochlorothiazide dosage, please talk to your doctor, nurse, or pharmacist.