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from eMedTV.comAngiotensin II Receptor Blockers (ARBs)
Combining Exforge with ARBs can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Cyclosporine
The amlodipine component of Exforge may increase the level of cyclosporine in the blood, perhaps increasing the risk for side effects. Because it is important for cyclosporine levels to fall within a certain range, your healthcare provider may need to check your blood levels and adjust your cyclosporine dosage if you start or stop taking Exforge.
Digoxin (Digitek, Lanoxin)
Exforge should be used carefully in people taking digoxin. Exforge can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
Eplerenone (Inspra)
Combining Exforge with eplerenone inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Exforge can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and Exforge together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Potassium
In general, potassium-containing products should not be used with Exforge, due to the risk of high potassium levels (hyperkalemia).
Simvastatin
Exforge increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
Triamterene Products
Combining Exforge with medications that contain triamterene can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD