Exforge Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Exforge is combined with any of the drugs listed above.
ACE Inhibitors
Combining Exforge with ACE inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly
(see Exforge and High Potassium for more information).
Alcohol
Drinking alcohol while taking Exforge can increase your risk of low
blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with Exforge.
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Exforge may interact with
amiloride. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
Angiotensin II Receptor Blockers (ARBs)
Combining Exforge with ARBs can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Digoxin (Digitek, Lanoxin)
Exforge should be used carefully in people taking
digoxin. Exforge can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
Eplerenone (Inspra)
Combining Exforge with eplerenone inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Exforge can interact with
NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have
congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and Exforge together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Potassium
In general, potassium-containing products should not be used with Exforge, due to the risk of high potassium levels (hyperkalemia).
Simvastatin
Exforge increases the level of
simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 20 mg per day.
Triamterene Products
Combining Exforge with medications that contain
triamterene can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
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