Exforge HCT Warnings and Precautions

Specific Exforge HCT Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Exforge HCT is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy. Exforge HCT can increase the risk of birth defects and other severe problems (see Exforge HCT and Pregnancy).
  • Exforge HCT can lower your blood pressure too much. Signs of low blood pressure include lightheadedness, dizziness, or fainting. Congestive heart failure, a recent heart attack, or surgery can increase your risk of low blood pressure.
  • If you have liver disease, your body may not metabolize Exforge HCT as well as it should. Therefore, you may require extra monitoring by your healthcare provider, and you may need to take a lower Exforge HCT dosage.
  • Drugs that contain hydrochlorothiazide (including this medication) can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. 
Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment (including surgery) may sometimes be necessary.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it. 
Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.
  • If you have severe coronary artery disease, there is a low possibility that taking Exforge HCT may increase your chances of worsening chest pain or heart attack.
  • Exforge HCT has not been studied in people with heart failure. Medications like Exforge HCT should be used with caution (and extra monitoring) in people with heart failure.
  • People with asthma have an increased risk of an allergy to hydrochlorothiazide, one of the active ingredients in Exforge HCT.
  • Exforge HCT can interact with a number of other medications (see Exforge HCT Interactions for more information).
  • It is known that hydrochlorothiazide passes through breast milk. It is unknown if the same is true for the other active ingredients in Exforge HCT. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Exforge HCT and Breastfeeding).
  • Exforge HCT may affect electrolytes in the blood (including sodium, calcium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:


    • Dry mouth and increased thirst
    • Weakness
    • Tiredness
    • Restlessness
    • Seizures
    • Confusion
    • Muscle pain and cramps
    • Decreased urine output
    • Weak or irregular heartbeat
    • Nausea and vomiting.


  • Hydrochlorothiazide (one of the active ingredients in Exforge HCT) has been reported to worsen systemic lupus erythematosus or, in some cases, to even cause the condition.
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