Precautions and Warnings With Eprosartan/HCTZ

Specific Eprosartan/HCTZ Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this blood pressure medication include the following:
 
  • Medications like eprosartan/HCTZ can cause potentially dangerous swelling below the surface of the skin, called angioedema, especially within the first month of treatment. Stop taking this drug and seek immediate medical care if you develop any symptoms of angioedema, such as difficulty breathing or swelling of the face, eyes, lips, tongue, hands, or feet.
 
  • Eprosartan/HCTZ may cause excessively low blood pressure, especially in people who are dehydrated (which can occur if you do not drink enough fluids or have vomiting and diarrhea), are on a salt-restricted diet, are on kidney dialysis, or have heart disease (such as congestive heart failure). Stay hydrated by drinking plenty of fluids while taking this medication, and let your healthcare provider know if you become dehydrated or experience dizziness, lightheadedness, or fainting.
 
 
  • This drug may cause increased blood sugar (hyperglycemia) in people with diabetes. If you have diabetes, your healthcare provider may need to adjust the dosage of your diabetes medication. In rare cases, it may cause diabetes in people who do not already have the condition.
 
  • Eprosartan/HCTZ can affect blood electrolytes, including sodium, potassium, magnesium, and calcium. Therefore, your healthcare provider may regularly check your electrolyte levels with a blood test while you are taking this medication. Contact your healthcare provider if you notice any symptoms of an electrolyte imbalance, such as:
 
    • Dry mouth
    • Thirst
    • Weakness
    • Extreme tiredness
    • Restlessness
    • Low blood pressure, which may cause dizziness or lightheadedness
    • Muscle tiredness, pains, or cramps
    • Nausea and vomiting
    • Decreased urination
    • Increased heart rate (tachycardia).
 
  • You should not use potassium supplements or salt substitutes that contain potassium without first checking with your healthcare provider. Eprosartan/HCTZ may cause an increase in blood potassium levels (hyperkalemia), and taking products that contain potassium may further increase potassium levels. People who have kidney disease or diabetes also have an increased risk for hyperkalemia from eprosartan/HCTZ.
 
  • Eprosartan/HCTZ may cause a drop in white blood cells, which could increase your risk for developing an infection. People with kidney disease may have an increased risk for this side effect. Contact your healthcare provider if you develop signs of an infection, such as a fever or sore throat.
 
  • This medication may worsen systemic lupus erythematosus (lupus or SLE for short) or, in some cases, may even cause the condition. It may also cause or worsen gout, a form of arthritis characterized by high uric acid levels.
 
  • If you are having any major surgery, make sure your healthcare provider knows you are taking eprosartan/HCTZ.
 
  • There have been reports of life-threatening allergic reactions occurring in certain people taking medications like eprosartan/HCTZ, including people undergoing kidney dialysis and people receiving bee or wasp venom to protect against sting allergies.

 

  • Drugs that contain hydrochlorothiazide (including this medication) can sometimes cause a potentially dangerous eye reaction (a particularly dangerous type of glaucoma). This reaction usually occurs within days to weeks of starting the drug. 
Because this reaction can permanently damage vision, let your healthcare provider know right away if you develop vision changes and/or eye pain. The main treatment for this reaction is to stop taking this medication, although other treatment (including surgery) may sometimes be necessary.
  • Eprosartan/HCTZ may cause a decrease in kidney function, especially in people who have kidney disease, elderly individuals, people taking nonsteroidal anti-inflammatory drugs (NSAIDs), or those with severe congestive heart failure (CHF). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking this medication.

Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems. In general, eprosartan/HCTZ is not recommended for people with severe kidney disease.

 
  • Eprosartan/HCTZ is a pregnancy Category C medication in the first trimester and Category D in the second and third trimesters. This means that this medicine may cause harm to an unborn child (see Teveten HCT and Pregnancy). Women who take this medication should take precautions to avoid pregnancy.
 
  • Hydrochlorothiazide (HCTZ), one of the components in this drug, passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Teveten HCT and Breastfeeding).
 
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